It’s no surprise that smoking for years can change the way the brain processes nicotine, creating a well-worn pattern of craving and satisfaction that’s difficult to break. But how soon does this cycle get started? And does nicotine actually alter structures in the brain to make dependence more likely? In the latest research, published in the journal Neuropsychopharmacology, Edythe London, a professor of psychiatry and pharmacology at University of California Los Angeles, and her team found that young smokers did have differences in a specific brain region compared with non smokers. Even more concerning, these differences emerged with a relatively light smoking habit of one pack or less of cigarettes a day. MORE: Children Exposed to More Brain-Harming Chemicals Than Ever Before London and her colleagues focused on a brain region called the insula, since previous studies in animal and adults showed that its size and volume were affected by smoking. Of the regions in the cortical, or memory, awareness and language parts of the brain, the insula contains the most receptors for nicotine. The region is responsible for decision-making and helping to establish a person’s conscious awareness of his internal state. In studies of stroke patients, smokers who lost function of the right insula in the stroke quit smoking, and reported feeling no cravings for nicotine. And in earlier studies London’s team conducted, they found a strong relationship between how much smokers who watched videos of people smoking experienced cravings for cigarettes and the activity of the insula, which lit up on PET scans. When London’s team looked at the brains of the 18 smoking teens and 24 non-smoking adolescents, aged 16 to 21 years, using structural MRI, they found no differences overall in the insula region. But a closer examination revealed that the right insula of the smokers was thinner than those of the nonsmokers. MORE: The FDA’s Frightening Anti-Smoking Campaign for Teens Hits Them Where It Hurts “The brain is still undergoing development when someone is in their late teens,” she says. “It’s possible that smoking during![]()
